Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast.
Identifieur interne : 000A79 ( Main/Exploration ); précédent : 000A78; suivant : 000A80Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast.
Auteurs : Matthieu Régnacq [France] ; Pierre Voisin [France] ; Yves Y. Sere [France] ; Bin Wan [France] ; Venty M S. Soeroso [France] ; Marianne Bernard [France] ; Nadine Camougrand [France] ; François-Xavier Bernard [France] ; Christine Barrault [France] ; Thierry Bergès [France]Source :
- Biochemical and biophysical research communications [ 1090-2104 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- biosynthèse : Acides gras.
- métabolisme : Azote, Saccharomyces cerevisiae.
- Autophagie, Métabolisme lipidique.
English descriptors
- KwdEn :
- MESH :
- chemical , biosynthesis : Fatty Acids.
- chemical , metabolism : Nitrogen.
- metabolism : Saccharomyces cerevisiae.
- Autophagy, Lipid Metabolism.
Abstract
Macroautophagy is a degradative pathway whereby cells encapsulate and degrade cytoplasmic material within endogenously-built membranes. Previous studies have suggested that autophagosome membranes originate from lipid droplets. However, it was recently shown that rapamycin could induce autophagy in cells lacking these organelles. Here we show that lipid droplet-deprived cells are unable to perform autophagy in response to nitrogen-starvation because of an accelerated lipid synthesis that is not observed with rapamycin. Using cerulenin, a potent inhibitor of fatty acid synthase, and exogenous addition of palmitic acid we could restore nitrogen-starvation induced autophagy in the absence of lipid droplets.
DOI: 10.1016/j.bbrc.2016.06.017
PubMed: 27270031
Affiliations:
- France
- Aquitaine, Nouvelle-Aquitaine, Poitou-Charentes
- Bordeaux, Gençay, Poitiers
- Université de Bordeaux, Université de Poitiers
Links toward previous steps (curation, corpus...)
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B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France. Electronic address: matthieu.regnacq@univ-poitiers.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Voisin, Pierre" sort="Voisin, Pierre" uniqKey="Voisin P" first="Pierre" last="Voisin">Pierre Voisin</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Sere, Yves Y" sort="Sere, Yves Y" uniqKey="Sere Y" first="Yves Y" last="Sere">Yves Y. Sere</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Wan, Bin" sort="Wan, Bin" uniqKey="Wan B" first="Bin" last="Wan">Bin Wan</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Soeroso, Venty M S" sort="Soeroso, Venty M S" uniqKey="Soeroso V" first="Venty M S" last="Soeroso">Venty M S. Soeroso</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Bernard, Marianne" sort="Bernard, Marianne" uniqKey="Bernard M" first="Marianne" last="Bernard">Marianne Bernard</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author><author><name sortKey="Camougrand, Nadine" sort="Camougrand, Nadine" uniqKey="Camougrand N" first="Nadine" last="Camougrand">Nadine Camougrand</name><affiliation wicri:level="4"><nlm:affiliation>CNRS, IBGC, UMR 5095, 1 rue Camille Saint-Saëns, 33000 Bordeaux, France; Université de Bordeaux, IBGC, UMR5095, 1 rue Camille Saint-Saëns, 33000 Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CNRS, IBGC, UMR 5095, 1 rue Camille Saint-Saëns, 33000 Bordeaux, France; Université de Bordeaux, IBGC, UMR5095, 1 rue Camille Saint-Saëns, 33000 Bordeaux</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName><orgName type="university">Université de Bordeaux</orgName></affiliation></author><author><name sortKey="Bernard, Francois Xavier" sort="Bernard, Francois Xavier" uniqKey="Bernard F" first="François-Xavier" last="Bernard">François-Xavier Bernard</name><affiliation wicri:level="3"><nlm:affiliation>BIOalternatives, 1 bis rue des Plantes, 86160 Gençay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>BIOalternatives, 1 bis rue des Plantes, 86160 Gençay</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Gençay</settlement></placeName></affiliation></author><author><name sortKey="Barrault, Christine" sort="Barrault, Christine" uniqKey="Barrault C" first="Christine" last="Barrault">Christine Barrault</name><affiliation wicri:level="3"><nlm:affiliation>BIOalternatives, 1 bis rue des Plantes, 86160 Gençay, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>BIOalternatives, 1 bis rue des Plantes, 86160 Gençay</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Gençay</settlement></placeName></affiliation></author><author><name sortKey="Berges, Thierry" sort="Berges, Thierry" uniqKey="Berges T" first="Thierry" last="Bergès">Thierry Bergès</name><affiliation wicri:level="4"><nlm:affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName><orgName type="university">Université de Poitiers</orgName></affiliation></author></analytic><series><title level="j">Biochemical and biophysical research communications</title><idno type="eISSN">1090-2104</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Autophagy (MeSH)</term><term>Fatty Acids (biosynthesis)</term><term>Lipid Metabolism (MeSH)</term><term>Nitrogen (metabolism)</term><term>Saccharomyces cerevisiae (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides gras (biosynthèse)</term><term>Autophagie (MeSH)</term><term>Azote (métabolisme)</term><term>Métabolisme lipidique (MeSH)</term><term>Saccharomyces cerevisiae (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Fatty Acids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nitrogen</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Acides gras</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Azote</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Autophagy</term><term>Lipid Metabolism</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Autophagie</term><term>Métabolisme lipidique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Macroautophagy is a degradative pathway whereby cells encapsulate and degrade cytoplasmic material within endogenously-built membranes. Previous studies have suggested that autophagosome membranes originate from lipid droplets. However, it was recently shown that rapamycin could induce autophagy in cells lacking these organelles. Here we show that lipid droplet-deprived cells are unable to perform autophagy in response to nitrogen-starvation because of an accelerated lipid synthesis that is not observed with rapamycin. Using cerulenin, a potent inhibitor of fatty acid synthase, and exogenous addition of palmitic acid we could restore nitrogen-starvation induced autophagy in the absence of lipid droplets.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27270031</PMID><DateCompleted><Year>2017</Year><Month>05</Month><Day>29</Day></DateCompleted><DateRevised><Year>2019</Year><Month>04</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1090-2104</ISSN><JournalIssue CitedMedium="Internet"><Volume>477</Volume><Issue>1</Issue><PubDate><Year>2016</Year><Month>08</Month><Day>12</Day></PubDate></JournalIssue><Title>Biochemical and biophysical research communications</Title><ISOAbbreviation>Biochem Biophys Res Commun</ISOAbbreviation></Journal><ArticleTitle>Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast.</ArticleTitle><Pagination><MedlinePgn>33-39</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0006-291X(16)30935-4</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.bbrc.2016.06.017</ELocationID><Abstract><AbstractText>Macroautophagy is a degradative pathway whereby cells encapsulate and degrade cytoplasmic material within endogenously-built membranes. Previous studies have suggested that autophagosome membranes originate from lipid droplets. However, it was recently shown that rapamycin could induce autophagy in cells lacking these organelles. Here we show that lipid droplet-deprived cells are unable to perform autophagy in response to nitrogen-starvation because of an accelerated lipid synthesis that is not observed with rapamycin. Using cerulenin, a potent inhibitor of fatty acid synthase, and exogenous addition of palmitic acid we could restore nitrogen-starvation induced autophagy in the absence of lipid droplets.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Régnacq</LastName><ForeName>Matthieu</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France. Electronic address: matthieu.regnacq@univ-poitiers.fr.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Voisin</LastName><ForeName>Pierre</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sere</LastName><ForeName>Yves Y</ForeName><Initials>YY</Initials><AffiliationInfo><Affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wan</LastName><ForeName>Bin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Soeroso</LastName><ForeName>Venty M S</ForeName><Initials>VMS</Initials><AffiliationInfo><Affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernard</LastName><ForeName>Marianne</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Camougrand</LastName><ForeName>Nadine</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>CNRS, IBGC, UMR 5095, 1 rue Camille Saint-Saëns, 33000 Bordeaux, France; Université de Bordeaux, IBGC, UMR5095, 1 rue Camille Saint-Saëns, 33000 Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernard</LastName><ForeName>François-Xavier</ForeName><Initials>FX</Initials><AffiliationInfo><Affiliation>BIOalternatives, 1 bis rue des Plantes, 86160 Gençay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barrault</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>BIOalternatives, 1 bis rue des Plantes, 86160 Gençay, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bergès</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Laboratoire Signalisation & Transports Ioniques Membranaires (STIM) - CNRS ERL 7368, Université de Poitiers, Bat. B36, TSA 51106, 1 rue Georges Bonnet, 86073 Poitiers Cedex 9, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>06</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Biochem Biophys Res Commun</MedlineTA><NlmUniqueID>0372516</NlmUniqueID><ISSNLinking>0006-291X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005227">Fatty Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>N762921K75</RegistryNumber><NameOfSubstance UI="D009584">Nitrogen</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D001343" MajorTopicYN="Y">Autophagy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005227" MajorTopicYN="N">Fatty Acids</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="Y">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050356" MajorTopicYN="Y">Lipid Metabolism</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009584" MajorTopicYN="N">Nitrogen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012441" MajorTopicYN="N">Saccharomyces cerevisiae</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Autophagy</Keyword><Keyword MajorTopicYN="Y">Fatty acid</Keyword><Keyword MajorTopicYN="Y">Fatty acid synthase</Keyword><Keyword MajorTopicYN="Y">Lipid droplets</Keyword><Keyword MajorTopicYN="Y">Rapamycin</Keyword><Keyword MajorTopicYN="Y">Saccharomyces cerevisiae</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>05</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>06</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>5</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27270031</ArticleId><ArticleId IdType="pii">S0006-291X(16)30935-4</ArticleId><ArticleId IdType="doi">10.1016/j.bbrc.2016.06.017</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li><li>Poitou-Charentes</li></region><settlement><li>Bordeaux</li><li>Gençay</li><li>Poitiers</li></settlement><orgName><li>Université de Bordeaux</li><li>Université de Poitiers</li></orgName></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Regnacq, Matthieu" sort="Regnacq, Matthieu" uniqKey="Regnacq M" first="Matthieu" last="Régnacq">Matthieu Régnacq</name></region><name sortKey="Barrault, Christine" sort="Barrault, Christine" uniqKey="Barrault C" first="Christine" last="Barrault">Christine Barrault</name><name sortKey="Berges, Thierry" sort="Berges, Thierry" uniqKey="Berges T" first="Thierry" last="Bergès">Thierry Bergès</name><name sortKey="Bernard, Francois Xavier" sort="Bernard, Francois Xavier" uniqKey="Bernard F" first="François-Xavier" last="Bernard">François-Xavier Bernard</name><name sortKey="Bernard, Marianne" sort="Bernard, Marianne" uniqKey="Bernard M" first="Marianne" last="Bernard">Marianne Bernard</name><name sortKey="Camougrand, Nadine" sort="Camougrand, Nadine" uniqKey="Camougrand N" first="Nadine" last="Camougrand">Nadine Camougrand</name><name sortKey="Sere, Yves Y" sort="Sere, Yves Y" uniqKey="Sere Y" first="Yves Y" last="Sere">Yves Y. Sere</name><name sortKey="Soeroso, Venty M S" sort="Soeroso, Venty M S" uniqKey="Soeroso V" first="Venty M S" last="Soeroso">Venty M S. Soeroso</name><name sortKey="Voisin, Pierre" sort="Voisin, Pierre" uniqKey="Voisin P" first="Pierre" last="Voisin">Pierre Voisin</name><name sortKey="Wan, Bin" sort="Wan, Bin" uniqKey="Wan B" first="Bin" last="Wan">Bin Wan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Increased fatty acid synthesis inhibits nitrogen starvation-induced autophagy in lipid droplet-deficient yeast.
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